자료유형  

 학위논문

Control Number  

0017164169

International Standard Book Number  

9798342715676

Dewey Decimal Classification Number  

547

Main Entry-Personal Name  

Gavin, Joshua T.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Minnesota., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

223 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-05, Section: B.

General Note  

Advisor: Roberts, Courtney C.

Dissertation Note  

Thesis (Ph.D.)--University of Minnesota, 2024.

Summary, Etc.  

요약Molecules with halogen atoms have many applications. In direct applications, halogenated molecules are seen in many marketed pharmaceuticals and continue to represent a growing proportion year-to-year. They also find applications in agrochemicals, polymers, and materials, and the unique properties halogenation imparts to products has been difficult to replicate by other means. Additionally, halogen-containing molecules have indirect applications for many more products because a halogen-free chemical may succeed from a synthetic intermediate containing a halogen atom. Through reactions such as Pd-catalyzed couplings, halogenated materials have become a regular feature in molecular syntheses. Thus, the synthesis of halogen-containing molecules is a vital part toward supporting the growth of the pharmaceuticals, agrochemicals, and materials industries. New methods to access these products in a more efficient manner benefits many industries. This dissertation discusses two distinct strategies to synthesize valuable halogenated products. First, the application of redox-active ligands with transition-metal catalysis is considered especially with early transition metals. The combination of redox-active ligands with relatively redox-innocent early transition metals enabled a method for synthesis of gem-difluorostyrenes. This process occurs via radical-polar crossover, a mechanism new to early-transition metals. Second, synthesis of halogen-containing products was shown by exploiting known reactivity of arynes. This method involves functionalization with amine nucleophiles followed by a rapid halogen-transfer that competes with other undesirable pathways.

Subject Added Entry-Topical Term  

Organic chemistry.

Subject Added Entry-Topical Term  

Inorganic chemistry.

Subject Added Entry-Topical Term  

Molecular chemistry.

Index Term-Uncontrolled  

Aryne

Index Term-Uncontrolled  

Catalysis

Index Term-Uncontrolled  

Early transition metals

Index Term-Uncontrolled  

Halogen

Added Entry-Corporate Name  

University of Minnesota Chemistry

Host Item Entry  

Dissertations Abstracts International. 86-05B.

Electronic Location and Access  

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Control Number  

joongbu:653892