자료유형  

 학위논문

Control Number  

0017162224

International Standard Book Number  

9798383222119

Dewey Decimal Classification Number  

540

Main Entry-Personal Name  

Karschney, Laura Jacquelyn.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Washington., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

89 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

General Note  

Advisor: Rathod, Pradipsinh K.;Theberge, Ashleigh B.

Dissertation Note  

Thesis (Ph.D.)--University of Washington, 2024.

Summary, Etc.  

요약This dissertation discusses malaria epidemiology, pathogenesis, and drug discovery projects. Chapter 1 presents background on malaria, its lifecycle, the history of antimalarials and development of resistance, and the Malaria Evolution in South Asia International Center of Excellence for Malaria Research. Chapter 2 details demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary hospital in the southwestern state of Goa, India. Chapter 3 presents a dynamic cohort study conducted in seven remote villages of the northeastern state of Assam, India and the impact of longitudinal malaria diagnosis and treatment on the remote tribal population. Chapter 4 details the bioactivity of a secondary metabolite of a marine symbiotic bacterium against sexual and asexual Plasmodium falciparum. The work presented in this dissertation demonstrates how aspects of different scientific disciplines may be utilized in combination to better understand the biology and community impacts of a major infectious disease and to respond to the urgent need for new antimicrobials.

Subject Added Entry-Topical Term  

Chemistry.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Epidemiology.

Subject Added Entry-Topical Term  

Microbiology.

Index Term-Uncontrolled  

Assam

Index Term-Uncontrolled  

Goa

Index Term-Uncontrolled  

MESA-ICEMR

Index Term-Uncontrolled  

Pathogenesis

Index Term-Uncontrolled  

Plasmodium falciparum

Index Term-Uncontrolled  

Tartrolon E

Added Entry-Corporate Name  

University of Washington Chemistry

Host Item Entry  

Dissertations Abstracts International. 86-01B.

Electronic Location and Access  

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Control Number  

joongbu:653754