자료유형  

 학위논문

Control Number  

0016932877

International Standard Book Number  

9798379867577

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

Zhang, Bei.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pittsburgh., 2021

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2021

Physical Description  

1 online resource(37 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-01, Section: A.

General Note  

Advisor: Li, Song.

Dissertation Note  

Thesis (M.Sc.)--University of Pittsburgh, 2021.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Immunotherapies harness the host immune system to elicit durable and safer antitumor effects. But due to the cancer immune escape mechanisms, the therapeutic outcomes of immunotherapies are under expectations. Researchers have struggled for decades to develop strategies to make this attractive idea work better and to figure out the underlying mechanisms. In recent years, numerous reports indicated that the altered epigenetic modifications may play a critical role in tumor immune escape. The agents that can reprogram cells to a more normal status like demethylating agents were also demonstrated to potentiate immunotherapies. In this study, we designed and synthesized an ultrasmall pro-drug nanocarrier for co-delivery of a DNA demethylating agent azacitidine and an immune modulator R848. The small size nanoparticles could efficiently penetrate and deliver the combination therapies to tumor core and reduce the distribution in other major organs. These nanoparticles PAza-R848 effectively inhibited the tumor growth. In addition, they significantly increased the numbers of tumor-infiltrated CD45+ cells, and the percentages of CD4+ and CD8+ T cells and dendritic cells, which may contribute to the improved antitumor efficacy.

Subject Added Entry-Topical Term  

DNA methylation.

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Acids.

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Metastasis.

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Immunotherapy.

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Cytotoxicity.

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Cancer therapies.

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Polymerization.

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Cytokines.

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Immunology.

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Flow cytometry.

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Biomedical materials.

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Chromatography.

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Potassium.

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Breast cancer.

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Drug dosages.

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Ethanol.

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Polymers.

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Spleen.

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Antigen presentation.

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Liver.

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Lymphocytes.

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Chemical bonds.

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Bone marrow.

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Tumors.

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Biochemistry.

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Biomedical engineering.

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Cellular biology.

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Chemistry.

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Materials science.

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Oncology.

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Pharmaceutical sciences.

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Polymer chemistry.

Subject Added Entry-Topical Term  

Therapy.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 85-01A.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:643635