자료유형  

 학위논문

Control Number  

0016932843

International Standard Book Number  

9798379849023

Dewey Decimal Classification Number  

600

Main Entry-Personal Name  

Bhanot, Jay Sharma.

Publication, Distribution, etc. (Imprint  

[S.l.] : Purdue University., 2022

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2022

Physical Description  

1 online resource(176 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

General Note  

Advisor: McLuckey, Scott A.

Dissertation Note  

Thesis (Ph.D.)--Purdue University, 2022.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약In the last thirty years, ion/ion reactions have been developed and applied to answer increasingly difficult analytical problems across a variety of industries. This requires the constant development of instrumentation that can enable work with the analyte modalities of highest impact. Such analytes have become increasingly high in molecular weight precluding many analysis techniques, such as mass spectrometry. In this work, a commercial quadrupole time-of-flight mass spectrometer was modified and adapted to support the analysis of high-mass bio-ions using ion/ion reactions. Using a highly modified instrument, novel capabilities and theory were developed around the analysis and detection of ions with m/z ratios as high as 400,000 m/zand 2.2 mDa. These capabilities enabled and benefitted the analysis of polymers, peptides, and proteins and in this work was demonstrated as an effective instrument a variety of applications. By using data generated on this apparatus, the rapid characterization of PS 80 samples using MATLAB programs to aide in peak identification, native ion parking, and novel ETD reagents were completed. Given the expanding role of biological systems in all areas of science, the development, characterization, and utilization of a highly versatile mass spectrometer is described herein.

Subject Added Entry-Topical Term  

Polymers.

Subject Added Entry-Topical Term  

Mass spectrometry.

Subject Added Entry-Topical Term  

Electrodes.

Subject Added Entry-Topical Term  

Blood vessels.

Subject Added Entry-Topical Term  

Oxidation.

Subject Added Entry-Topical Term  

Charged particles.

Subject Added Entry-Topical Term  

Ions.

Subject Added Entry-Topical Term  

Solvents.

Subject Added Entry-Topical Term  

Electric fields.

Subject Added Entry-Topical Term  

Fatty acids.

Subject Added Entry-Topical Term  

Molecular weight.

Subject Added Entry-Topical Term  

Scientific imaging.

Subject Added Entry-Topical Term  

Chromatography.

Subject Added Entry-Topical Term  

Electric currents.

Subject Added Entry-Topical Term  

Polypeptides.

Subject Added Entry-Topical Term  

Analytical chemistry.

Subject Added Entry-Topical Term  

Atomic physics.

Subject Added Entry-Topical Term  

Chemistry.

Subject Added Entry-Topical Term  

Electromagnetics.

Subject Added Entry-Topical Term  

Physics.

Subject Added Entry-Topical Term  

Polymer chemistry.

Added Entry-Corporate Name  

Purdue University.

Host Item Entry  

Dissertations Abstracts International. 85-01B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:643621