Material Type  

 학위논문

 

0016935011

Date and Time of Latest Transaction  

20240214101842

ISBN  

9798380847919

DDC  

616

Author  

Mizes, Kevin G. C.

Title/Author  

Distinct Neural Substrates for Flexible and Automatic Motor Sequence Execution - [electronic resource]

Publish Info  

[S.l.] : Harvard University., 2023

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Material Info  

1 online resource(153 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-05, Section: B.

General Note  

Advisor: Olveczky, Bence P.

학위논문주기  

Thesis (Ph.D.)--Harvard University, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Abstracts/Etc  

요약The ability to flexibly sequence movements into longer actions enables our rich behavioral repertoire. However, this feat can be cognitively demanding, leading to slow and error-prone performances. To achieve fast and fluid performance, the same motor sequence is practiced extensively until it is automatic. The neural circuits underlying automatic motor execution are thought to differ from those for executing flexible ones, but this distinction is not well understood. To address this, we trained rats to perform sequences of three lever presses in both flexible sessions - where cues instructed the sequence order - and in automatic ones - where a single uncued sequence was repeated. We found that neural activity in sensorimotor striatum primarily encodes low-level movement kinematics, regardless of the execution mode or sequence, whereas motor cortex activity reflects more high-level sequence information. Consequently, lesions to sensorimotor striatum affect the movement kinematics across both flexible and automatic movement sequences. This disrupted high-level sequence structure for only the automatic, but not visually-guided flexible behavior, which were rescued by the external cues, mirroring results from Parkinsonian patients. Lesions to motor cortex disrupted flexible sequence execution, indicating its vital role in high-level sequencing of motor elements. Interestingly, motor cortex lesions also affected automatic sequences when animals trained on both automatic and flexible modes execution modes, but for animals trained only on the automatic task, performance was largely spared, suggesting flexible performance interferes with subcortical consolidation of automatic sequences. This work provides important insights into the hierarchical and distributed control of flexible and automatic motor sequences and characterizes the circumstances under which the motor cortex is essential for sequence execution.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Molecular biology.

Index Term-Uncontrolled  

Neural substrates

Index Term-Uncontrolled  

Automatic motor execution

Index Term-Uncontrolled  

Motor sequence

Index Term-Uncontrolled  

Performance

Index Term-Uncontrolled  

Motor elements

Added Entry-Corporate Name  

Harvard University Biophysics

Host Item Entry  

Dissertations Abstracts International. 85-05B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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소장사항  

202402 2024

Control Number  

joongbu:643424