자료유형  

 학위논문

Control Number  

0016932002

International Standard Book Number  

9798379657185

Dewey Decimal Classification Number  

600

Main Entry-Personal Name  

Ritchie, Christopher.

Publication, Distribution, etc. (Imprint  

[S.l.] : Stanford University., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(131 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

General Note  

Advisor: Gao, Alex;Kim, Peter;Li, Lingyin.

Dissertation Note  

Thesis (Ph.D.)--Stanford University, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Throughout our lifetimes, our bodies encounter a plethora of threats on the cellular level, including pathogen infection, cellular damage, and the development of cancer. When these threats are not properly detected, they can lead to serious health problems, including death. Thankfully, our cells are pre-programmed with an array of innate immune pathways that can quickly respond to threats by detecting specific molecular danger signals that indicate a threat is present. Of these innate immune pathways, the cGAMP-STING pathway is on the forefront of the immune response due to its ability to detect mislocalized double stranded DNA (dsDNA). Since mislocalized dsDNA is a danger signal nearly ubiquitous with cellular threats, the cGAMP-STING pathway is essential for responding to most threats, including pathogen infection, cellular damage, and cancer. Given the extensive role of the cGAMP-STING pathway in defending against threats, regulation of the pathway is crucial to ensure its proper function. In this work, I show how intercellular pathway activation is regulated through cell-type specific transporters of the pathway's agonist, cGAMP, and how intracellular pathway activation is regulated through the E3-ubiquitin ligase PELI2.

Subject Added Entry-Topical Term  

Infections.

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Cancer.

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Endoplasmic reticulum.

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Biochemistry.

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Polymerization.

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Binding sites.

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Cytokines.

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Autophagy.

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Genes.

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Apoptosis.

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Cell cycle.

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Polymers.

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Dendritic cells.

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Regulation.

Subject Added Entry-Topical Term  

Bacterial infections.

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Lymphocytes.

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Antigens.

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Phosphorylation.

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Viral infections.

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Enzymes.

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Interferon.

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Transcription factors.

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Cellular biology.

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Immunology.

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Pathology.

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Pharmaceutical sciences.

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Polymer chemistry.

Subject Added Entry-Topical Term  

Virology.

Added Entry-Corporate Name  

Stanford University.

Host Item Entry  

Dissertations Abstracts International. 84-12B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:643225