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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations- [electronic resource]
Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations- [electronic resource]
상세정보
- 자료유형
- 학위논문
- Control Number
- 0016933286
- International Standard Book Number
- 9798379908218
- Dewey Decimal Classification Number
- 610
- Main Entry-Personal Name
- Ochs, Alexander Richard.
- Publication, Distribution, etc. (Imprint
- [S.l.] : University of Washington., 2023
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- Physical Description
- 1 online resource(131 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- General Note
- Advisor: Boyle, Patrick M.
- Dissertation Note
- Thesis (Ph.D.)--University of Washington, 2023.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Summary, Etc.
- 요약This dissertation discusses the application of light-induced stimulation (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac electrophysiology computational models. Chapter 2 provides a basic explanation of optogenetic actuators (opsins), covering past applications (both experimental and computational) in cardiac tissue at various scales. Chapter 3 examines the efficacy of expressing an anion-conducting opsin (GtACR1) to terminate atrial and ventricular arrhythmias in 3D patient-derived models. Additionally, a 2-state photocurrent model for GtACR1 is introduced. Chapter 4 studies the use of subthreshold optogenetic stimulation to up- and down-regulate early afterdepolarization propensity (cell-scale) and related premature ventricular complexes (organ-scale) in patient models. Chapter 5 evaluates the use of optogenetic stimulation to modulate spontaneous beating in pluripotent stem cell-derived cardiomyocytes (cell-scale) and graft-to-host excitation in 2D, histology-derived tissue models (tissue-scale). The work presented here demonstrates how optogenetic stimulation can be used to control the initiation and suppression of arrhythmias in computational models across a variety of arrhythmia-prone conditions.
- Subject Added Entry-Topical Term
- Biomedical engineering.
- Subject Added Entry-Topical Term
- Physiology.
- Subject Added Entry-Topical Term
- Computational physics.
- Subject Added Entry-Topical Term
- Bioengineering.
- Index Term-Uncontrolled
- Arrhythmia
- Index Term-Uncontrolled
- Cardiac
- Index Term-Uncontrolled
- Cardiomyocyte
- Index Term-Uncontrolled
- Electrophysiology
- Index Term-Uncontrolled
- Myocardial infarction
- Index Term-Uncontrolled
- Optogenetics
- Added Entry-Corporate Name
- University of Washington Bioengineering
- Host Item Entry
- Dissertations Abstracts International. 85-01B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:643061
MARC
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■020 ▼a9798379908218
■035 ▼a(MiAaPQ)AAI30527163
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aOchs, Alexander Richard.
■24510▼aControlling Arrhythmias Using Optogenetic Actuators in Computational Simulations▼h[electronic resource]
■260 ▼a[S.l.]▼bUniversity of Washington. ▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a1 online resource(131 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-01, Section: B.
■500 ▼aAdvisor: Boyle, Patrick M.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aThis dissertation discusses the application of light-induced stimulation (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac electrophysiology computational models. Chapter 2 provides a basic explanation of optogenetic actuators (opsins), covering past applications (both experimental and computational) in cardiac tissue at various scales. Chapter 3 examines the efficacy of expressing an anion-conducting opsin (GtACR1) to terminate atrial and ventricular arrhythmias in 3D patient-derived models. Additionally, a 2-state photocurrent model for GtACR1 is introduced. Chapter 4 studies the use of subthreshold optogenetic stimulation to up- and down-regulate early afterdepolarization propensity (cell-scale) and related premature ventricular complexes (organ-scale) in patient models. Chapter 5 evaluates the use of optogenetic stimulation to modulate spontaneous beating in pluripotent stem cell-derived cardiomyocytes (cell-scale) and graft-to-host excitation in 2D, histology-derived tissue models (tissue-scale). The work presented here demonstrates how optogenetic stimulation can be used to control the initiation and suppression of arrhythmias in computational models across a variety of arrhythmia-prone conditions.
■590 ▼aSchool code: 0250.
■650 4▼aBiomedical engineering.
■650 4▼aPhysiology.
■650 4▼aComputational physics.
■650 4▼aBioengineering.
■653 ▼aArrhythmia
■653 ▼aCardiac
■653 ▼aCardiomyocyte
■653 ▼aElectrophysiology
■653 ▼aMyocardial infarction
■653 ▼aOptogenetics
■690 ▼a0541
■690 ▼a0719
■690 ▼a0216
■690 ▼a0202
■71020▼aUniversity of Washington▼bBioengineering.
■7730 ▼tDissertations Abstracts International▼g85-01B.
■773 ▼tDissertation Abstract International
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933286▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
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