자료유형  

 학위논문

Control Number  

0016935486

International Standard Book Number  

9798380198677

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

McHenry, Michael.

Publication, Distribution, etc. (Imprint  

[S.l.] : Case Western Reserve University., 2021

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2021

Physical Description  

1 online resource(129 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

General Note  

Advisor: Bush, William.

Dissertation Note  

Thesis (Ph.D.)--Case Western Reserve University, 2021.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Tuberculosis (TB) is a major public health problem, causing more deaths globally than any other pathogen prior to COVID19. It is also the leading cause of death among people infected with human immunodeficiency virus (HIV). Susceptibility to TB can be influenced by human genetic variation. However, factors underlying variation in TB severity are less well studied. Clinical severity is an important phenotype that encompasses prognosis, patient experience, and risk of mortality. Thus, it is important to study severity, as it can help us better understand patients' quality of life, disease experience, and to predict survival among TB patients receiving treatment. There is also evidence that MTB genetic variation as delineated by phylogenetic lineage can affect TB disease severity, when considered simultaneously with human genetic variations and the interaction between the two. Many genetic studies of TB stop short of linking these genetic effects to biological function. The proposed study will address these fundamental gaps by 1) studying the genomic underpinnings of active TB severity using a meaningful, replicable, and validated clinical phenotype; 2) demonstrating evidence of co-evolution between humans and MTB on a population level how it affects severity; and 3) bridging the gap between genetic variants and immunological function by studying gene expression in the macrophage response. The overall goal is to examine how genomic variation in humans and MTB impact the immunological response to active TB disease and how this correlates with clinical severity.

Subject Added Entry-Topical Term  

Medicine.

Subject Added Entry-Topical Term  

Epidemiology.

Subject Added Entry-Topical Term  

Genetics.

Subject Added Entry-Topical Term  

Public health.

Index Term-Uncontrolled  

Tuberculosis

Index Term-Uncontrolled  

Genetic epidemiology

Index Term-Uncontrolled  

Infectious disease

Index Term-Uncontrolled  

Evolution

Index Term-Uncontrolled  

Immunological function

Added Entry-Corporate Name  

Case Western Reserve University Epidemiology and Biostatistics

Host Item Entry  

Dissertations Abstracts International. 85-03B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:642911