자료유형  

 학위논문

Control Number  

0016932339

International Standard Book Number  

9798379613006

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Deng, Wenying.

Publication, Distribution, etc. (Imprint  

[S.l.] : Harvard University., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(213 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

General Note  

Advisor: Coull, Brent.

Dissertation Note  

Thesis (Ph.D.)--Harvard University, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Gaussian Process Regression has become widely used in biomedical research in recent years, particularly for studying the intricate and nonlinear impacts of multivariate genetic or environmental exposures. This dissertation proposes methods for estimating and testing nonlinear effects and/or estimating variable importance with uncertainty quantification. Chapter 1 focuses on hypothesis testing, while Chapter 2 and 3 address general variable importance estimation problems. In Chapter 1, we develop an R package CVEK, which introduces a suite of flexible machine learning models and robust hypothesis tests for learning the joint nonlinear effects of multiple covariates in limited samples. It implements the Cross-validated Ensemble of Kernels (CVEK), an ensemble-based kernel machine learning method that adaptively learns the joint nonlinear effect of multiple covariates from data, and provides powerful hypothesis tests for both main effects of features and interactions among features. The R Package CVEK provides a flexible, easy-to-use implementation of CVEK, and offers a wide range of choices for the kernel family (for instance, polynomial, radial basis functions, Matern, neural network, and others), model selection criteria, ensembling method (averaging, exponential weighting, cross-validated stacking), and the type of hypothesis test (asymptotic or parametric bootstrap). Through extensive simulations we demonstrate the validity and robustness of this approach, and provide practical guidelines on how to design an estimation strategy for optimal performance in different data scenarios.In Chapter 2, we propose a simple and unified framework for nonlinear variable importance estimation that incorporates uncertainty in the prediction function and is compatible with a wide range of machine learning models (e.g., tree ensembles, kernel methods, neural networks, etc). In particular, for a learned nonlinear model f(x), we consider quantifying the importance of an input variable xj using the integrated partial derivative Ψj = ∥ ∂/∂xj f(x)∥2PX . We then (1) provide a principled approach for quantifying uncertainty in variable importance by deriving its posterior distribution, and (2) show that the approach is generalizable even to non-differentiable models such as tree ensembles. Rigorous Bayesian nonparametric theorems are derived to guarantee the posterior consistency and asymptotic uncertainty of the proposed approach. Extensive simulations and experiments on healthcare benchmark datasets confirm that the proposed algorithm outperforms existing classical and recent variable selection methods.In Chapter 3, we develop a versatile framework that can be applied to continuous, count, and binary responses. The primary aim is to estimate the variable importance scores using various machine learning models, including tree ensembles, kernel methods, neural networks, and others. Additionally, the proposed framework accounts for the impact of confounding variables and provides a way to assess the uncertainty associated with variable importance scores. Subsequently, we present a systematic method to estimate the uncertainty in variable importance by computing its posterior distribution. We derive Bayesian nonparametric theorems that ensure the posterior consistency and asymptotic uncertainty of the proposed approach. The efficacy of the proposed algorithm is validated through comprehensive simulations and experiments on socioeconomic benchmark datasets, indicating superior performance compared to existing traditional and contemporary variable selection techniques.

Subject Added Entry-Topical Term  

Biostatistics.

Subject Added Entry-Topical Term  

Statistics.

Index Term-Uncontrolled  

Gaussian Process Regression

Index Term-Uncontrolled  

Hypothesis testing

Index Term-Uncontrolled  

Machine learning

Index Term-Uncontrolled  

Statistical inference

Index Term-Uncontrolled  

Variable selection

Added Entry-Corporate Name  

Harvard University Biostatistics

Host Item Entry  

Dissertations Abstracts International. 84-12B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:642335