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Uncovering Key Determinants of Skeletal Muscle Repair- [electronic resource]
Uncovering Key Determinants of Skeletal Muscle Repair- [electronic resource]
상세정보
- 자료유형
- 학위논문
- Control Number
- 0016931852
- International Standard Book Number
- 9798379615833
- Dewey Decimal Classification Number
- 574
- Main Entry-Personal Name
- Horwitz, Naftali.
- Publication, Distribution, etc. (Imprint
- [S.l.] : Harvard University., 2023
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- Physical Description
- 1 online resource(110 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
- General Note
- Advisor: Wagers, Amy.
- Dissertation Note
- Thesis (Ph.D.)--Harvard University, 2023.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Summary, Etc.
- 요약Skeletal muscle regeneration is a complex process that allows damaged muscle tissue to be repaired and restored to its original function. This process involves a series of coordinated events, including inflammation, satellite cell activation and proliferation, myoblast differentiation and fusion, and muscle fiber maturation. The success of muscle regeneration relies on the ability of satellite cells to differentiate into functional myoblasts, which can fuse with existing fibers or form new fibers to replace damaged or lost muscle tissue. Various factors, such as age, disease, and injury, can impair muscle regeneration, leading to muscle wasting and weakness. Understanding the cellular and molecular mechanisms underlying skeletal muscle regeneration is crucial for developing effective therapeutic strategies to enhance muscle repair and function in various pathologies.In this thesis I sought to understand this regenerative process further by interrogating the earliest cell autonomous mechanisms that transition a muscle stem cell from quiescence to activation. Specifically, I describe Fos, a member of the AP-I family of transcription factors and a classical oncogene, as an early regulator of satellite cell activity which initiates key stem cell functions, including cell cycle entry, proliferative expansion, and muscle regeneration, via induction of ''pro-regenerative'' target genes that stimulate cell migration, division, and differentiation.
- Subject Added Entry-Topical Term
- Biochemistry.
- Subject Added Entry-Topical Term
- Cellular biology.
- Subject Added Entry-Topical Term
- Molecular biology.
- Index Term-Uncontrolled
- Skeletal muscle regeneration
- Index Term-Uncontrolled
- Muscle tissue
- Index Term-Uncontrolled
- Satellite cell activation
- Index Term-Uncontrolled
- Muscle regeneration
- Index Term-Uncontrolled
- Stem cell
- Added Entry-Corporate Name
- Harvard University Chemical Biology
- Host Item Entry
- Dissertations Abstracts International. 84-12B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:641981
MARC
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■006m o d
■007cr#unu||||||||
■020 ▼a9798379615833
■035 ▼a(MiAaPQ)AAI30425830
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aHorwitz, Naftali.▼0(orcid)0000-0003-2714-7152
■24510▼aUncovering Key Determinants of Skeletal Muscle Repair▼h[electronic resource]
■260 ▼a[S.l.]▼bHarvard University. ▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a1 online resource(110 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 84-12, Section: B.
■500 ▼aAdvisor: Wagers, Amy.
■5021 ▼aThesis (Ph.D.)--Harvard University, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aSkeletal muscle regeneration is a complex process that allows damaged muscle tissue to be repaired and restored to its original function. This process involves a series of coordinated events, including inflammation, satellite cell activation and proliferation, myoblast differentiation and fusion, and muscle fiber maturation. The success of muscle regeneration relies on the ability of satellite cells to differentiate into functional myoblasts, which can fuse with existing fibers or form new fibers to replace damaged or lost muscle tissue. Various factors, such as age, disease, and injury, can impair muscle regeneration, leading to muscle wasting and weakness. Understanding the cellular and molecular mechanisms underlying skeletal muscle regeneration is crucial for developing effective therapeutic strategies to enhance muscle repair and function in various pathologies.In this thesis I sought to understand this regenerative process further by interrogating the earliest cell autonomous mechanisms that transition a muscle stem cell from quiescence to activation. Specifically, I describe Fos, a member of the AP-I family of transcription factors and a classical oncogene, as an early regulator of satellite cell activity which initiates key stem cell functions, including cell cycle entry, proliferative expansion, and muscle regeneration, via induction of ''pro-regenerative'' target genes that stimulate cell migration, division, and differentiation.
■590 ▼aSchool code: 0084.
■650 4▼aBiochemistry.
■650 4▼aCellular biology.
■650 4▼aMolecular biology.
■653 ▼aSkeletal muscle regeneration
■653 ▼aMuscle tissue
■653 ▼aSatellite cell activation
■653 ▼aMuscle regeneration
■653 ▼aStem cell
■690 ▼a0487
■690 ▼a0379
■690 ▼a0307
■71020▼aHarvard University▼bChemical Biology.
■7730 ▼tDissertations Abstracts International▼g84-12B.
■773 ▼tDissertation Abstract International
■790 ▼a0084
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931852▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
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