Material Type  

 학위논문

 

0016932734

Date and Time of Latest Transaction  

20240214100538

ISBN  

9798379842062

DDC  

621

Author  

Eshraghi, Javad.

Title/Author  

Methods and Analysis of Multiphase Flow and Interfacial Phenomena in Medical Devices - [electronic resource]

Publish Info  

[S.l.] : Purdue University., 2022

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2022

Material Info  

1 online resource(187 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

General Note  

Advisor: Vlachos, Pavlos P.

학위논문주기  

Thesis (Ph.D.)--Purdue University, 2022.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Abstracts/Etc  

요약Cavitation, liquid slosh, and splashes are ubiquitous in science and engineering. However, these phenomena are not fully understood. Yet to date, we do not understand when or why sometimes the splash seals, and other times does not. Regarding cavitation, a high temporal resolution method is needed to characterize this phenomenon. The low temporal resolution of experimental data suggests a model-based analysis of this problem. However, high-fidelity models are not always available, and even for these models, the sensitivity of the model outputs to the initial input parameters makes this method less reliable since some initial inputs are not experimentally measurable. As for sloshing, the air-liquid interface area and hydrodynamic stress for the liquid slosh inside a confined accelerating cylinder have not been experimentally measured due to the challenges for direct measurement.This dissertation provides the first detailed analysis and physical explanations for the abovementioned phenomena. These have consequences for diverse applications such as biomedical, diving, sound propagation in oceans, ocean oxygenation, and energy harvesting.First, we developed an analytical model to describe the trajectory and dynamics of the splash curtain in the water entry of hydrophobic spheres and validated it with a series of experiments. We elucidated the dynamics of splash curtain and discovered the existence of a critical dimensionless number that predicts the occurrence of the surface seal.As for the cavitation modeling, we proposed a robust characterization tool based on a novel state observer-based data-assimilation technique to overcome the limitations in the existing methods. We fused time-resolved cavitation bubble diameter measurements with the governing model to yield enhanced Spatiotemporal prediction of the cavitation bubble dynamics in this new autonomous technique.We then employed the data assimilation modeling to investigate the dynamics of a single air bubble exposed to an acoustic pressure field induced by a cavitation bubble using a unique combination of theory and experiment. We elucidated the effects of acoustic source intensity, the distance from the acoustic source, and air bubble size on the air bubble final oscillation regime. We also used data assimilation modeling to quantify cavitation intensity in autoinjector medical devices to assess the impact of cavitation on therapeutic protein.Furthermore, a set of experiments by conducting simultaneous PIV and shadowgraphy were used to investigate the interfacial motion and hydrodynamic shear due to the acceleration/deceleration during the autoinjector insertion that might cause therapeutic protein aggregation.

Subject Added Entry-Topical Term  

Propagation.

Subject Added Entry-Topical Term  

Cavitation.

Subject Added Entry-Topical Term  

Wavelet transforms.

Subject Added Entry-Topical Term  

Viscosity.

Subject Added Entry-Topical Term  

Vortices.

Subject Added Entry-Topical Term  

Interferometry.

Subject Added Entry-Topical Term  

Bubbles.

Subject Added Entry-Topical Term  

Lasers.

Subject Added Entry-Topical Term  

Data assimilation.

Subject Added Entry-Topical Term  

Medical research.

Subject Added Entry-Topical Term  

Medical equipment.

Subject Added Entry-Topical Term  

Energy.

Subject Added Entry-Topical Term  

Acoustics.

Subject Added Entry-Topical Term  

Reynolds number.

Subject Added Entry-Topical Term  

Shear stress.

Subject Added Entry-Topical Term  

Fluid mechanics.

Subject Added Entry-Topical Term  

Mathematics.

Subject Added Entry-Topical Term  

Mechanics.

Subject Added Entry-Topical Term  

Medicine.

Subject Added Entry-Topical Term  

Optics.

Added Entry-Corporate Name  

Purdue University.

Host Item Entry  

Dissertations Abstracts International. 85-01B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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소장사항  

202402 2024

Control Number  

joongbu:641592