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The Association of VMAT2 Gene Polymorphisms with the Development of Schizophrenia- [electronic resource]
The Association of VMAT2 Gene Polymorphisms with the Development of Schizophrenia- [electronic resource]
상세정보
- 자료유형
- 학위논문
- Control Number
- 0016933749
- International Standard Book Number
- 9798380261241
- Dewey Decimal Classification Number
- 510
- Main Entry-Personal Name
- Cenname, Alexis.
- Publication, Distribution, etc. (Imprint
- [S.l.] : University of Pittsburgh., 2023
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- Physical Description
- 1 online resource(30 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 85-03, Section: A.
- General Note
- Advisor: Carlson, Jenna.
- Dissertation Note
- Thesis (M.Sc.)--University of Pittsburgh, 2023.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Summary, Etc.
- 요약Objective: To investigate the association between common single nucleotide polymorphisms (SNPs) in the vesicular monoamine transporter type 2 (VMAT2) gene and a diagnosis of schizophrenia in the US population.Methods:968 individuals with a diagnosis of schizophrenia were ancestry-matched to healthy controls to create a final cohort of 1,936 individuals. Diagnosis criteria was determined from Electronic Health Records provided by the AllofUs Research Program. Additive and dominant logistic regression analyses were done for the promoter SNPs rs363324 and rs363371. Additional stratified analyses were performed using sex and ancestry variables.Results: No significant results were observed for rs363324 and rs363371 using the additive model. The dominant model suggested a protective effect for rs363324 for the entire cohort (p = 0.007; OR = 0.75[0.61, 0.92]) and within the African ancestral group (p = 0.028; OR= 0.76[0.56, 0.97]). Stratification by sex did not give significant results for either genotype model, nor did stratification by ancestry+sex.Conclusion:Premature mortality rates and the need for targeted treatments in schizophrenia make it an important disease to study for public health. This study found that 'GA' and 'AA' genotypes have an equal protective effect from the development of schizophrenia for rs363324. Unlike previous studies, the results for rs363371 were not significant. Future studies should use a larger sample size and include variables concerning environmental factors.
- Subject Added Entry-Topical Term
- Sample size.
- Subject Added Entry-Topical Term
- Schizophrenia.
- Subject Added Entry-Topical Term
- Electronic health records.
- Subject Added Entry-Topical Term
- Dopamine.
- Subject Added Entry-Topical Term
- Drug abuse.
- Subject Added Entry-Topical Term
- Parkinsons disease.
- Subject Added Entry-Topical Term
- Mental disorders.
- Subject Added Entry-Topical Term
- Health risk assessment.
- Subject Added Entry-Topical Term
- Psychosis.
- Subject Added Entry-Topical Term
- Genomes.
- Subject Added Entry-Topical Term
- Mental health.
- Subject Added Entry-Topical Term
- Privacy.
- Subject Added Entry-Topical Term
- Genotype & phenotype.
- Subject Added Entry-Topical Term
- Genes.
- Subject Added Entry-Topical Term
- Eigenvectors.
- Subject Added Entry-Topical Term
- Clinical psychology.
- Subject Added Entry-Topical Term
- Genetics.
- Subject Added Entry-Topical Term
- Health sciences.
- Subject Added Entry-Topical Term
- Information science.
- Subject Added Entry-Topical Term
- Mathematics.
- Subject Added Entry-Topical Term
- Neurosciences.
- Subject Added Entry-Topical Term
- Psychology.
- Added Entry-Corporate Name
- University of Pittsburgh.
- Host Item Entry
- Dissertations Abstracts International. 85-03A.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:641300
MARC
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■020 ▼a9798380261241
■035 ▼a(MiAaPQ)AAI30556099
■035 ▼a(MiAaPQ)Pittsburgh44818
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a510
■1001 ▼aCenname, Alexis.
■24510▼aThe Association of VMAT2 Gene Polymorphisms with the Development of Schizophrenia▼h[electronic resource]
■260 ▼a[S.l.]▼bUniversity of Pittsburgh. ▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a1 online resource(30 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-03, Section: A.
■500 ▼aAdvisor: Carlson, Jenna.
■5021 ▼aThesis (M.Sc.)--University of Pittsburgh, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aObjective: To investigate the association between common single nucleotide polymorphisms (SNPs) in the vesicular monoamine transporter type 2 (VMAT2) gene and a diagnosis of schizophrenia in the US population.Methods:968 individuals with a diagnosis of schizophrenia were ancestry-matched to healthy controls to create a final cohort of 1,936 individuals. Diagnosis criteria was determined from Electronic Health Records provided by the AllofUs Research Program. Additive and dominant logistic regression analyses were done for the promoter SNPs rs363324 and rs363371. Additional stratified analyses were performed using sex and ancestry variables.Results: No significant results were observed for rs363324 and rs363371 using the additive model. The dominant model suggested a protective effect for rs363324 for the entire cohort (p = 0.007; OR = 0.75[0.61, 0.92]) and within the African ancestral group (p = 0.028; OR= 0.76[0.56, 0.97]). Stratification by sex did not give significant results for either genotype model, nor did stratification by ancestry+sex.Conclusion:Premature mortality rates and the need for targeted treatments in schizophrenia make it an important disease to study for public health. This study found that 'GA' and 'AA' genotypes have an equal protective effect from the development of schizophrenia for rs363324. Unlike previous studies, the results for rs363371 were not significant. Future studies should use a larger sample size and include variables concerning environmental factors.
■590 ▼aSchool code: 0178.
■650 4▼aSample size.
■650 4▼aSchizophrenia.
■650 4▼aElectronic health records.
■650 4▼aDopamine.
■650 4▼aDrug abuse.
■650 4▼aParkinsons disease.
■650 4▼aMental disorders.
■650 4▼aHealth risk assessment.
■650 4▼aPsychosis.
■650 4▼aGenomes.
■650 4▼aMental health.
■650 4▼aPrivacy.
■650 4▼aGenotype & phenotype.
■650 4▼aGenes.
■650 4▼aEigenvectors.
■650 4▼aClinical psychology.
■650 4▼aGenetics.
■650 4▼aHealth sciences.
■650 4▼aInformation science.
■650 4▼aMathematics.
■650 4▼aNeurosciences.
■650 4▼aPsychology.
■690 ▼a0347
■690 ▼a0622
■690 ▼a0369
■690 ▼a0566
■690 ▼a0723
■690 ▼a0405
■690 ▼a0317
■690 ▼a0621
■71020▼aUniversity of Pittsburgh.
■7730 ▼tDissertations Abstracts International▼g85-03A.
■773 ▼tDissertation Abstract International
■790 ▼a0178
■791 ▼aM.Sc.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933749▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
