자료유형  

 학위논문

Control Number  

0016933747

International Standard Book Number  

9798380260220

Dewey Decimal Classification Number  

600

Main Entry-Personal Name  

McNulty, Joseph Michael.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pittsburgh., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(68 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: A.

General Note  

Advisor: Morelli, Adrian;Mattila, Joshua;Mailliard, Robbie.

Dissertation Note  

Thesis (M.Sc.)--University of Pittsburgh, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약As HIV becomes a more chronic and manageable condition, research of the disease has shifted. ART has played a large role in raising the life expectancy of people living with HIV. However, it has some drawbacks and has created a landscape for the need of a novel and more effective therapeutic to eradicate HIV. The dendritic cell (DC) shows promise as a role player in this novel therapeutic due to its ability to link both the innate and adaptive arm of the immune systems. Several studies have shown that type-1 polarized DCs (DC1s) are more effective at driving latency reversal and CTL responses, when stimulated with CD40L, a costimulatory molecule derived from CD4+ T helper cells that has many immunologic functions. A clinically relevant type-1 polarized DC vaccine platform called the alpha-DC1 (αDC1) developed at the University of Pittsburgh is currently being studied as an alternative to more commonly used DCbased vaccines, sometimes referred to as DC2. To accurately compare the two DC subsets and to gain a better understanding of each cell type and their interaction with other immune cells, we performed tests to detail the characterization of these DC-based vaccine platforms and their responsiveness to the T helper cell signal CD40L. We assess their differences through characterization of their phenotype, morphology, cytokine production, single cell transcriptomics, and extracellular vesicle production. It is understood that the knowledge obtained from this study would give researchers an in-depth understanding of these clinically relevant DC subsets so that they may be used more effectively as an HIV therapeutic.

Subject Added Entry-Topical Term  

Infections.

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Software.

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Pathogens.

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Nanoparticles.

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Cytokines.

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Immunology.

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Chronic illnesses.

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Extracellular vesicles.

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Amino acids.

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Genomics.

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Apoptosis.

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Drug therapy.

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Human immunodeficiency virus--HIV.

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Dendritic cells.

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Spectrum analysis.

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Immune system.

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Medical research.

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Lymphocytes.

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Tumor necrosis factor-TNF.

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Antigens.

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Analytical chemistry.

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Cellular biology.

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Chemistry.

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Genetics.

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Medicine.

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Nanotechnology.

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Optics.

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Therapy.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 85-03A.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:641295