자료유형  

 학위논문

Control Number  

0016933477

International Standard Book Number  

9798379728205

Dewey Decimal Classification Number  

612

Main Entry-Personal Name  

Schrader, Lauren A.

Publication, Distribution, etc. (Imprint  

[S.l.] : The University of Wisconsin - Madison., 2022

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2022

Physical Description  

1 online resource(325 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

General Note  

Advisor: Bradfield, Christopher.

Dissertation Note  

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Over the past decades, evidence has been accumulating regarding the key roles circadian rhythms play in human health. From the core clock machinery in every cell to the myriad of physiological processes under circadian control, these rhythms are responsible for the orchestration of a complex symphony inside human bodies, attuned to environmental conditions. When these rhythms fall out of alignment in various ways, this circadian disruption serves as a risk factor in the development of many chronic diseases, including cancers and metabolic syndrome. While a large body of research has been undertaken to understand more about circadian rhythms, circadian disruption, and their health impacts in humans, gaps in understanding remain. First, much of the established knowledge regarding circadian rhythms in humans has come from small, homogeneous healthy samples in experimental settings, often creating conditions of extreme circadian disruption. Population health studies offer an excellent alternative to learn more about circadian rhythms in real-world conditions, but a lack of consensus and easily-reproducible approaches for approximating circadian rhythms has limited this utilization. Further, while much is established regarding the canonical behavior of core clock genes responsible for circadian rhythms, less is known about the ways their expression patterns and downstream clock-controlled genes' expression are altered during circadian disruption, as a potential mechanism in the development of pathological outcomes such as metabolic syndrome. In this manuscript, we first review the current state of knowledge concerning the relationships between circadian disruption, subsequent alterations to core clock gene expression, and their association with metabolic syndrome pathologies in humans, with a discussion of remaining knowledge gaps. The second chapter describes a methodology for the estimation of circadian rhythm states via sleep/wake data collected from actigraph devices, in a sample of adults recruited from the general population. Chapter three details RNA sequencing investigations to determine whether group-level patterns in circadian-oscillating genes could be observed in using morning and afternoon human blood samples, as a means to estimate which genes are detectable as circadian-oscillating. Chapter four summarizes an assessment of differential gene expression between groups from a population health study with estimated circadian disruption to those with consistent schedules. Finally, chapter five outlines preliminary investigations proceeding from this work, as well as additional experiments and future directions to pursue based on the findings and data generated from this work. Together, this thesis provides new considerations for the study and understanding of circadian rhythms and their impact on human health.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Epidemiology.

Subject Added Entry-Topical Term  

Genetics.

Index Term-Uncontrolled  

Circadian disruption

Index Term-Uncontrolled  

Circadian rhythms

Index Term-Uncontrolled  

Gene expression

Index Term-Uncontrolled  

Human health

Index Term-Uncontrolled  

Population health study

Added Entry-Corporate Name  

The University of Wisconsin - Madison Cellular and Molecular Biology

Host Item Entry  

Dissertations Abstracts International. 84-12B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:640232