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Modular Engineering and In Vivo Library Selection of Tissue-Targeting Protein Nanoparticles- [electronic resource]
Modular Engineering and In Vivo Library Selection of Tissue-Targeting Protein Nanoparticles- [electronic resource]
상세정보
- 자료유형
- 학위논문
- Control Number
- 0016931726
- International Standard Book Number
- 9798379908638
- Dewey Decimal Classification Number
- 610
- Main Entry-Personal Name
- Olshefsky, Audrey Ellen.
- Publication, Distribution, etc. (Imprint
- [S.l.] : University of Washington., 2023
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- Physical Description
- 1 online resource(135 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- General Note
- Advisor: Pun, Suzie H.;King, Neil P.
- Dissertation Note
- Thesis (Ph.D.)--University of Washington, 2023.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Summary, Etc.
- 요약Targeted delivery remains one of the greatest challenges and opportunities in drug development. In Chapter 1, I review these challenges and opportunities through the lens of the principles of applying self-assembling protein nanomaterials to therapeutic delivery. In Chapter 2, I report an in vivo library selection platform based on protein nanoparticles that encapsulate their own genome. Our selection platform offers a unique tool to optimize protein-based therapeutic performance in a living mammal, a complex physiological environment that cannot yet be comprehensively modeled in silico or in vitro, and to identify targeting ligands of interest. In Chapter 3, I report results towards modularly reprogramming synthetic nucleocapsids for targeted chemotherapeutic delivery by altering both the displayed targeting domains and the encapsulated cargo. I discuss potential future directions in Chapter 4. Together, these results provide new insights and methods for developing self-assembling nanomaterials for in vivo targeted delivery.
- Subject Added Entry-Topical Term
- Bioengineering.
- Subject Added Entry-Topical Term
- Biochemistry.
- Subject Added Entry-Topical Term
- Pharmaceutical sciences.
- Index Term-Uncontrolled
- Nanomaterials
- Index Term-Uncontrolled
- Drug development
- Index Term-Uncontrolled
- Therapeutic performance
- Index Term-Uncontrolled
- Physiological environment
- Index Term-Uncontrolled
- Living mammal
- Added Entry-Corporate Name
- University of Washington Bioengineering
- Host Item Entry
- Dissertations Abstracts International. 85-01B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:640201
MARC
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■020 ▼a9798379908638
■035 ▼a(MiAaPQ)AAI30420295
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aOlshefsky, Audrey Ellen.
■24510▼aModular Engineering and In Vivo Library Selection of Tissue-Targeting Protein Nanoparticles▼h[electronic resource]
■260 ▼a[S.l.]▼bUniversity of Washington. ▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a1 online resource(135 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-01, Section: B.
■500 ▼aAdvisor: Pun, Suzie H.;King, Neil P.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aTargeted delivery remains one of the greatest challenges and opportunities in drug development. In Chapter 1, I review these challenges and opportunities through the lens of the principles of applying self-assembling protein nanomaterials to therapeutic delivery. In Chapter 2, I report an in vivo library selection platform based on protein nanoparticles that encapsulate their own genome. Our selection platform offers a unique tool to optimize protein-based therapeutic performance in a living mammal, a complex physiological environment that cannot yet be comprehensively modeled in silico or in vitro, and to identify targeting ligands of interest. In Chapter 3, I report results towards modularly reprogramming synthetic nucleocapsids for targeted chemotherapeutic delivery by altering both the displayed targeting domains and the encapsulated cargo. I discuss potential future directions in Chapter 4. Together, these results provide new insights and methods for developing self-assembling nanomaterials for in vivo targeted delivery.
■590 ▼aSchool code: 0250.
■650 4▼aBioengineering.
■650 4▼aBiochemistry.
■650 4▼aPharmaceutical sciences.
■653 ▼aNanomaterials
■653 ▼aDrug development
■653 ▼aTherapeutic performance
■653 ▼aPhysiological environment
■653 ▼aLiving mammal
■690 ▼a0202
■690 ▼a0487
■690 ▼a0572
■71020▼aUniversity of Washington▼bBioengineering.
■7730 ▼tDissertations Abstracts International▼g85-01B.
■773 ▼tDissertation Abstract International
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16931726▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
