자료유형  

 학위논문

Control Number  

0016931694

International Standard Book Number  

9798379708498

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Slezak, Tomasz.

Publication, Distribution, etc. (Imprint  

[S.l.] : The University of Chicago., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(135 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

General Note  

Advisor: Kossiakoff, Anthony.

Dissertation Note  

Thesis (Ph.D.)--The University of Chicago, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Antibodies have the unique property of recognizing and binding specific antigens, making them valuable tools for studying biological processes and developing new disease treatments. The discovery of the technology that allowed for monoclonal antibody production has revolutionized the whole biological field. It has led to the creation of several methods used daily in every modern laboratory. The growing number of antibodies used in the clinic and laboratories require reagent personalization, which usually requires a time-consuming and ineffective chemical manipulation that can influence the antibody's performance. This thesis describes engineering an easy, highthroughput platform that allows for antibody personalization in a plug-and-play fashion. It discusses in detail the protein engineering approach that led to the platform's development, followed by the development of various applications. Finally, the thesis explains the generation of ultra-high affinity antibodies that recognize SARS-CoV-2 and their applications for virus neutralization and detection using the plug-and-play technology described above. The presented technology can potentially improve antibody-based research by the broader scientific community and can revolutionize future clinical approaches for many therapies. 

Subject Added Entry-Topical Term  

Biochemistry.

Subject Added Entry-Topical Term  

Biophysics.

Subject Added Entry-Topical Term  

Immunology.

Index Term-Uncontrolled  

Antibody engineering

Index Term-Uncontrolled  

Cell biology

Index Term-Uncontrolled  

Phage display

Index Term-Uncontrolled  

Protein engineering

Index Term-Uncontrolled  

Structural biology

Added Entry-Corporate Name  

The University of Chicago Biochemistry and Molecular Biophysics

Host Item Entry  

Dissertations Abstracts International. 84-12B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:640127