자료유형  

 학위논문

Control Number  

0016932328

International Standard Book Number  

9798379605285

Dewey Decimal Classification Number  

530

Main Entry-Personal Name  

Williams, LaNell Alexandria.

Publication, Distribution, etc. (Imprint  

[S.l.] : Harvard University., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(87 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

General Note  

Advisor: Manoharan, Vinothan.

Dissertation Note  

Thesis (Ph.D.)--Harvard University, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Self-assembly is a vital part of the RNA virus life cycle. The assembly of viral coat proteins around viral RNA occurs both in vivo and in vitro, suggesting that viral capsid assembly may be driven by minimization of free energy. To better understand this process, we study the assembly of bacteriophage MS2 virus-like particles (VLPs as a function of coat-protein concentration, RNA concentration, ionic strength, temperature, and viscosity. We use dynamic light scattering, transmission electron microscopy, and gelelectrophoresis to determinethesize distribution, morphology, and composition of the assembled structures. We show how the morphology of MS2 VLPs varies with these conditions, and we relate these results to a model of assembly involving nucleation and growth.

Subject Added Entry-Topical Term  

Physics.

Subject Added Entry-Topical Term  

Biophysics.

Subject Added Entry-Topical Term  

Condensed matter physics.

Subject Added Entry-Topical Term  

Biology.

Index Term-Uncontrolled  

Virus life cycle

Index Term-Uncontrolled  

RNA

Index Term-Uncontrolled  

Bacteriophage

Index Term-Uncontrolled  

Dynamic light scattering

Index Term-Uncontrolled  

Electron microscopy

Added Entry-Corporate Name  

Harvard University Physics

Host Item Entry  

Dissertations Abstracts International. 84-12B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:639681