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Engineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design- [electronic resource]
Engineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design- [electronic resource]
상세정보
- Material Type
- 학위논문
- 0016933166
- Date and Time of Latest Transaction
- 20240214101212
- ISBN
- 9798379906849
- DDC
- 574
- Author
- Dosey, Anne.
- Title/Author
- Engineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design - [electronic resource]
- Publish Info
- [S.l.] : University of Washington., 2023
- Publish Info
- Ann Arbor : ProQuest Dissertations & Theses, 2023
- Material Info
- 1 online resource(70 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- General Note
- Advisor: King, Neil P.
- 학위논문주기
- Thesis (Ph.D.)--University of Washington, 2023.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Abstracts/Etc
- 요약Protein nanoparticle-based vaccines are a promising platform, shown to be efficacious in preventing disease against a variety of pathogens. Building on their success, increasing our understanding of how nanoparticle vaccines elicit immune responses will aid both in our general understanding of immunology and also in designing improved vaccines. This work centers on influenza hemagglutinin (HA) nanoparticle vaccine design. It starts with the design of HA 'trihead' nanoparticle vaccines, that incorporate several layers of immune refocusing to increase breadth and potency in responses elicited against the HA head. Trihead design was then adapted onto several strains of HA, with the ultimate goal of creating a new platform for seasonal influenza vaccines. Lastly, the interaction of antibodies and HA ectodomain nanoparticles was explored as a means to elucidate mechanisms of their immunogenicity.
- Subject Added Entry-Topical Term
- Biochemistry.
- Subject Added Entry-Topical Term
- Pathology.
- Subject Added Entry-Topical Term
- Nanoscience.
- Subject Added Entry-Topical Term
- Immunology.
- Index Term-Uncontrolled
- Protein nanoparticle
- Index Term-Uncontrolled
- Nanoparticle vaccines
- Index Term-Uncontrolled
- Antibodies
- Index Term-Uncontrolled
- Immune responses
- Added Entry-Corporate Name
- University of Washington Biochemistry
- Host Item Entry
- Dissertations Abstracts International. 85-01B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- 소장사항
-
202402 2024
- Control Number
- joongbu:639430
MARC
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■00520240214101212
■006m o d
■007cr#unu||||||||
■020 ▼a9798379906849
■035 ▼a(MiAaPQ)AAI30525564
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aDosey, Anne.
■24510▼aEngineering Influenza HA Nanoparticles to Better Understand Their Immune Responses and Improve Vaccine Design▼h[electronic resource]
■260 ▼a[S.l.]▼bUniversity of Washington. ▼c2023
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2023
■300 ▼a1 online resource(70 p.)
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-01, Section: B.
■500 ▼aAdvisor: King, Neil P.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2023.
■506 ▼aThis item must not be sold to any third party vendors.
■520 ▼aProtein nanoparticle-based vaccines are a promising platform, shown to be efficacious in preventing disease against a variety of pathogens. Building on their success, increasing our understanding of how nanoparticle vaccines elicit immune responses will aid both in our general understanding of immunology and also in designing improved vaccines. This work centers on influenza hemagglutinin (HA) nanoparticle vaccine design. It starts with the design of HA 'trihead' nanoparticle vaccines, that incorporate several layers of immune refocusing to increase breadth and potency in responses elicited against the HA head. Trihead design was then adapted onto several strains of HA, with the ultimate goal of creating a new platform for seasonal influenza vaccines. Lastly, the interaction of antibodies and HA ectodomain nanoparticles was explored as a means to elucidate mechanisms of their immunogenicity.
■590 ▼aSchool code: 0250.
■650 4▼aBiochemistry.
■650 4▼aPathology.
■650 4▼aNanoscience.
■650 4▼aImmunology.
■653 ▼aProtein nanoparticle
■653 ▼aNanoparticle vaccines
■653 ▼aAntibodies
■653 ▼aImmune responses
■690 ▼a0487
■690 ▼a0565
■690 ▼a0982
■690 ▼a0571
■71020▼aUniversity of Washington▼bBiochemistry.
■7730 ▼tDissertations Abstracts International▼g85-01B.
■773 ▼tDissertation Abstract International
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2023
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933166▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202402▼f2024
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