자료유형  

 학위논문

Control Number  

0016935272

International Standard Book Number  

9798380364690

Dewey Decimal Classification Number  

617.6

Main Entry-Personal Name  

Venkateswaran, Vidhya.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, Los Angeles., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(124 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: A.

General Note  

Advisor: Nishimura, Ichiro;Pasaniuc, Bogdan.

Dissertation Note  

Thesis (Ph.D.)--University of California, Los Angeles, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Bioinformatics and computational methods play an important role in advancing medical research with their ability to leverage large datasets, including data from electronic health records (EHR) linked biobanks. Precision medicine can benefit from leveraging a more comprehensive picture of a patient's genotypes and phenotypic presentation for targeted interventions and treatment planning. In this work, I discuss the applications of bioinformatics methods in the UCLA ATLAS biobank, in evaluating craniofacial traits and their risk factors: specifically, head and neck cancer and tobacco use disorder. First, I describe phenome-wide and lab-wide association analysis pipelines that leverage the breadth of the available information in the biobank, and the results of preliminary investigations of the phenome-wide and laboratory-wide associations of a genetic predisposition to tobacco use disorder. Next, I present the results of an evaluation of the predictive performance of a tobacco use polygenic score across different genetic ancestry groups and further discuss the differences in disease presentations in tobacco use-predisposed individuals with and without a history of the associated tobacco use behavior. Next, I employ these pipelines and statistical methods in the examination of the interplay of serum bilirubin, tobacco use, head and neck, and lung cancer. I present the results of this project, examining the effect of environmental and genetic factors on serum bilirubin and associations with head and neck cancer and lung cancer. Lastly, I propose a research project to examine the germline risk factors for oropharyngeal cancer and discuss the future directions of this work.

Subject Added Entry-Topical Term  

Dentistry.

Subject Added Entry-Topical Term  

Bioinformatics.

Subject Added Entry-Topical Term  

Information science.

Index Term-Uncontrolled  

Medical research

Index Term-Uncontrolled  

Electronic health records

Index Term-Uncontrolled  

Biobanks

Index Term-Uncontrolled  

Craniofacial traits

Index Term-Uncontrolled  

Genetic factors

Index Term-Uncontrolled  

Tobacco use

Added Entry-Corporate Name  

University of California, Los Angeles Oral Biology 0615

Host Item Entry  

Dissertations Abstracts International. 85-03A.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:639104