자료유형  

 학위논문

Control Number  

0016933058

International Standard Book Number  

9798379911362

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Pranoto, Inez Keiko Arlyne.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Washington., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(61 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

General Note  

Advisor: Kwon, Young.

Dissertation Note  

Thesis (Ph.D.)--University of Washington, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Many tumors recapitulate the developmental and differentiation program of their tissue of origin, a basis for tumor cell heterogeneity. Although stem-cell-like tumor cells are well-studied, the roles of tumor cells undergoing differentiation in inducing the phenotypes associated with advanced cancers remains to be elucidated. Here, we employ Drosophila genetics to demonstrate that the native differentiation program of intestinal stem cells plays a key role in determining an intestinal tumor's capacity to invade and induce various non-tumor-autonomous phenotypes. The differentiation program that generates absorptive cells called enterocytes is aberrantly recapitulated in the intestinal tumors generated through activation of the Yap1 ortholog Yorkie. Elimination of tumor cells in the enterocyte lineage allows stem cell-like tumor cells to grow but suppresses invasiveness and reshapes various phenotypes associated with cachexia-like wasting by altering the expression of tumor-derived factors. Meanwhile, enriching the intermediately differentiated tumor cells in the enterocyte lineage promotes a more robust and quicker tumor growth that lacks cell invasive properties but enhances tumor-derived factors expression, resulting in a more advanced manifestation of cachexia-like wasting syndrome in the host. This study provides insight into how a native differentiation program determines a tumor's capacity to induce the phenotypes associated with advanced cancers and suggests that manipulating the differentiation programs co-opted in tumors might be a way to treat some complications of cancer, including cachexia.

Subject Added Entry-Topical Term  

Biochemistry.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Oncology.

Index Term-Uncontrolled  

Cell differentiation

Index Term-Uncontrolled  

Cachexia-like wasting syndrome

Index Term-Uncontrolled  

Tumor cell heterogeneity

Index Term-Uncontrolled  

Tumor cell invasiveness

Added Entry-Corporate Name  

University of Washington Biochemistry

Host Item Entry  

Dissertations Abstracts International. 85-01B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:639082