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Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry
Studies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry
상세정보
- 자료유형
- 학위논문
- Control Number
- 0015493512
- International Standard Book Number
- 9781687943507
- Dewey Decimal Classification Number
- 574
- Main Entry-Personal Name
- Huang, Xiaoxiao.
- Publication, Distribution, etc. (Imprint
- [Sl] : Northwestern University, 2019
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2019
- Physical Description
- 155 p
- General Note
- Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
- General Note
- Advisor: Kelleher, Neil L.
- Dissertation Note
- Thesis (Ph.D.)--Northwestern University, 2019.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Restrictions on Access Note
- This item must not be added to any third party search indexes.
- Summary, Etc.
- 요약Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic regulators through chromosomal translocations, mutations, and deletions is highly associated with tumorigenesis. NSD2 (MMSET/WHSC1) is a histone methyltransferase that catalyzes di-methylation of histone H3 lysine 36 (H3K36me2), a mark associated with gene activation. The overexpression of NSD2 in t(4
- Subject Added Entry-Topical Term
- Molecular biology
- Subject Added Entry-Topical Term
- Analytical chemistry
- Subject Added Entry-Topical Term
- Biochemistry
- Added Entry-Corporate Name
- Northwestern University Interdepartmental Biological Sciences (IBiS) Graduate Program
- Host Item Entry
- Dissertations Abstracts International. 81-05B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:569243
MARC
008200131s2019 c eng d■001000015493512
■00520200217182130
■020 ▼a9781687943507
■035 ▼a(MiAaPQ)AAI22618133
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aHuang, Xiaoxiao.
■24510▼aStudies of the Epigenetic Regulator NSD2 by Targeted and Quantitative Mass Spectrometry
■260 ▼a[Sl]▼bNorthwestern University▼c2019
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2019
■300 ▼a155 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 81-05, Section: B.
■500 ▼aAdvisor: Kelleher, Neil L.
■5021 ▼aThesis (Ph.D.)--Northwestern University, 2019.
■506 ▼aThis item must not be sold to any third party vendors.
■506 ▼aThis item must not be added to any third party search indexes.
■520 ▼aEpigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic regulators through chromosomal translocations, mutations, and deletions is highly associated with tumorigenesis. NSD2 (MMSET/WHSC1) is a histone methyltransferase that catalyzes di-methylation of histone H3 lysine 36 (H3K36me2), a mark associated with gene activation. The overexpression of NSD2 in t(4
■590 ▼aSchool code: 0163.
■650 4▼aMolecular biology
■650 4▼aAnalytical chemistry
■650 4▼aBiochemistry
■690 ▼a0307
■690 ▼a0486
■690 ▼a0487
■71020▼aNorthwestern University▼bInterdepartmental Biological Sciences (IBiS) Graduate Program.
■7730 ▼tDissertations Abstracts International▼g81-05B.
■773 ▼tDissertation Abstract International
■790 ▼a0163
■791 ▼aPh.D.
■792 ▼a2019
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T15493512▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202002▼f2020
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