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Application of Functional Optical Coherence Tomography Angiography in Neurovascular Research
Application of Functional Optical Coherence Tomography Angiography in Neurovascular Research
상세정보
- 자료유형
- 학위논문
- Control Number
- 0015490858
- International Standard Book Number
- 9781085779487
- Dewey Decimal Classification Number
- 535
- Main Entry-Personal Name
- Li, Yuandong.
- Publication, Distribution, etc. (Imprint
- [Sl] : University of Washington, 2019
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2019
- Physical Description
- 112 p
- General Note
- Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
- General Note
- Advisor: Wang, Ruikang K.
- Dissertation Note
- Thesis (Ph.D.)--University of Washington, 2019.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Restrictions on Access Note
- This item must not be added to any third party search indexes.
- Summary, Etc.
- 요약Optical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring backscattered or backreflected light.혻Its functional extension, OCT angiography (OCTA), analyzes the intrinsic scattering property of the heterogenous tissue bed to extract dynamic blood flow signals to the capillary level without a need of contrast agents. Aside from the commonly known application of OCTA in clinical ophthalmology for imaging the retinal blood flow in human subjects, the technique has recently emerged as a useful tool in pre-clinical neuroscience for imaging cerebral microcirculation and dynamics in rodent models. The main goal of this thesis is to progress with the application of OCT/OCTA in neurovascular research and solve questions in neurovascular functions and associated disorders, including ischemic stroke, aging, and Alzheimer's disease. To achieve this goal, firstly, novel mouse cranial window techniques will be developed together with series of OCTA algorithms to image the cerebral blood flow in mouse brain that covers capillary, pial and penetrating vessels. Then, a newly developed method, OCTA capillary velocimetry, will be applied to investigate the capillary flow pattern adjustment during neurovascular coupling and brain oxygenation. Next, vasodynamics of pial and penetrating arterioles of the cerebral collateral network will be unraveled in rodent models of ischemic stroke, upon which new details of a vascular self-protective mechanism will be revealed. Lastly, the multifunctional OCTA will be applied for a comprehensive investigation of aging-associated cerebral vasculature and blood flow changes that give indications to Alzheimer's disease.
- Subject Added Entry-Topical Term
- Bioengineering
- Subject Added Entry-Topical Term
- Neurosciences
- Subject Added Entry-Topical Term
- Physiology
- Subject Added Entry-Topical Term
- Histology
- Subject Added Entry-Topical Term
- Health sciences
- Subject Added Entry-Topical Term
- Optics
- Added Entry-Corporate Name
- University of Washington Bioengineering
- Host Item Entry
- Dissertations Abstracts International. 81-04B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:566841
MARC
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■00520200217181025
■020 ▼a9781085779487
■035 ▼a(MiAaPQ)AAI13858223
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a535
■1001 ▼aLi, Yuandong.
■24510▼aApplication of Functional Optical Coherence Tomography Angiography in Neurovascular Research
■260 ▼a[Sl]▼bUniversity of Washington▼c2019
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2019
■300 ▼a112 p
■500 ▼aSource: Dissertations Abstracts International, Volume: 81-04, Section: B.
■500 ▼aAdvisor: Wang, Ruikang K.
■5021 ▼aThesis (Ph.D.)--University of Washington, 2019.
■506 ▼aThis item must not be sold to any third party vendors.
■506 ▼aThis item must not be added to any third party search indexes.
■520 ▼aOptical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring backscattered or backreflected light.혻Its functional extension, OCT angiography (OCTA), analyzes the intrinsic scattering property of the heterogenous tissue bed to extract dynamic blood flow signals to the capillary level without a need of contrast agents. Aside from the commonly known application of OCTA in clinical ophthalmology for imaging the retinal blood flow in human subjects, the technique has recently emerged as a useful tool in pre-clinical neuroscience for imaging cerebral microcirculation and dynamics in rodent models. The main goal of this thesis is to progress with the application of OCT/OCTA in neurovascular research and solve questions in neurovascular functions and associated disorders, including ischemic stroke, aging, and Alzheimer's disease. To achieve this goal, firstly, novel mouse cranial window techniques will be developed together with series of OCTA algorithms to image the cerebral blood flow in mouse brain that covers capillary, pial and penetrating vessels. Then, a newly developed method, OCTA capillary velocimetry, will be applied to investigate the capillary flow pattern adjustment during neurovascular coupling and brain oxygenation. Next, vasodynamics of pial and penetrating arterioles of the cerebral collateral network will be unraveled in rodent models of ischemic stroke, upon which new details of a vascular self-protective mechanism will be revealed. Lastly, the multifunctional OCTA will be applied for a comprehensive investigation of aging-associated cerebral vasculature and blood flow changes that give indications to Alzheimer's disease.
■590 ▼aSchool code: 0250.
■650 4▼aBioengineering
■650 4▼aNeurosciences
■650 4▼aPhysiology
■650 4▼aHistology
■650 4▼aHealth sciences
■650 4▼aOptics
■690 ▼a0202
■690 ▼a0317
■690 ▼a0752
■690 ▼a0566
■690 ▼a0414
■690 ▼a0719
■71020▼aUniversity of Washington▼bBioengineering.
■7730 ▼tDissertations Abstracts International▼g81-04B.
■773 ▼tDissertation Abstract International
■790 ▼a0250
■791 ▼aPh.D.
■792 ▼a2019
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T15490858▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
■980 ▼a202002▼f2020
