자료유형  

 학위논문

Control Number  

0014996643

International Standard Book Number  

9780355829778

Dewey Decimal Classification Number  

540

Main Entry-Personal Name  

Ganapati, Shweta.

Publication, Distribution, etc. (Imprint  

[Sl] : University of Maryland, College Park, 2017

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2017

Physical Description  

350 p

General Note  

Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.

General Note  

Adviser: Lyle Isaacs.

Dissertation Note  

Thesis (Ph.D.)--University of Maryland, College Park, 2017.

Restrictions on Access Note  

This item is not available from ProQuest Dissertations & Theses.

Summary, Etc.  

요약The study of molecular containers has a prominent place in the scientific literature with many applications, including drug reversal. The clinical use of the cyclodextrin based reversal agent Bridion(TM) has greatly improved the post-operative s

Summary, Etc.  

요약Chapter 1 introduces molecular containers, CB[n], and reports the use of the acyclic CB[n] known as Calabadion 2 as a broad spectrum reversal agent for NMBAs in rats. It also proposes the potential use of molecular containers as reversal agents

Summary, Etc.  

요약Chapter 2 establishes that Calabadion 2 displays good to high levels of selectivity toward the NMBAs rocuronium, vecuronium, and cisatracurium both in vitro and based on simulations designed to capture the essence of the biological system. The e

Summary, Etc.  

요약Chapter 3 establishes that CB[n] based molecular containers - Calabadion 1, Calabadion 2, and CB[7] display higher affinities than p-sulfocalix[4]arene and HP-beta-cyclodextrin toward a panel of illicit drugs for which there are currently no USF

Summary, Etc.  

요약Chapter 4 discusses the synthesis and molecular recognition properties of three new acyclic CB[n] hosts IV-2a -- IV-2c which incorporate alkyl linkers of varying lengths- ethyl, hexyl, and decyl

Subject Added Entry-Topical Term  

Chemistry

Subject Added Entry-Topical Term  

Organic chemistry

Added Entry-Corporate Name  

University of Maryland, College Park Chemistry

Host Item Entry  

Dissertation Abstracts International. 79-10B(E).

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:557850