자료유형  

 학위논문

Control Number  

0014996556

International Standard Book Number  

9780438024113

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Baeza, Josue.

Publication, Distribution, etc. (Imprint  

[Sl] : The University of Wisconsin - Madison, 2017

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2017

Physical Description  

206 p

General Note  

Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.

General Note  

Adviser: John M. Denu.

Dissertation Note  

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2017.

Summary, Etc.  

요약Reversible N-epsilon-acetylation has emerged as a widespread and regulatory modification throughout the cell. First identified on N-terminal histone tails over 50 years ago, acetylation has now been identified on over 36,000 lysine sites on orga

Summary, Etc.  

요약In mitochondria, acetylation generally acts as an inhibitory modification, altering protein interactions, lowered enzymatic activity and mislocalization of mitochondrial proteins. In this case, acetylation acts as a rheostat, modulating the degr

Summary, Etc.  

요약The mechanism of mitochondrial protein acetylation remains unknown. While there is a wealth of data supporting a dynamic and regulatory role for acetylation within mitochondria, there is very little evidence for an enzyme-catalyzed reaction. How

Summary, Etc.  

요약Throughout my thesis research, I have utilized chemical, biochemical, proteomic, and cellular studies to characterize protein acetylation. Specifically, I developed a mass spectrometry based approach to directly quantify lysine acetylation stoic

Summary, Etc.  

요약Chapter 1 introduces lysine acetylation, the various processes controlling cellular levels including enzymatic and nonenzymatic, and why quantifying acetylation stoichiometry is needed. Chapter 2 discusses the mass spectrometry based method used

Subject Added Entry-Topical Term  

Biochemistry

Added Entry-Corporate Name  

The University of Wisconsin - Madison Biomolecular Chemistry

Host Item Entry  

Dissertation Abstracts International. 79-10B(E).

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:557759