자료유형  

 학위논문

Control Number  

0014996547

International Standard Book Number  

9780438159518

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Smith, Thomas P.

Publication, Distribution, etc. (Imprint  

[Sl] : The University of Wisconsin - Madison, 2016

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2016

Physical Description  

358 p

General Note  

Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.

General Note  

Adviser: Ronald T. Raines.

Dissertation Note  

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2016.

Summary, Etc.  

요약Boronic acids have been shown to interact with biological molecules including carbohydrates and reactive oxygen species (ROS). This variety of biological targets is due to the unique reactivity of boron that, within a physiological pH range, can

Summary, Etc.  

요약The development of therapeutic proteins is generating considerable interest. This interest is due to the high selectivity of proteins for a target and the high enzymatic activity a protein-based therapeutic can possess. There are, however, a num

Summary, Etc.  

요약In chapter 2, I describe the development of a discreet, small-molecule boronic acid-based delivery strategy for the delivery of native protein into the cytosol of a cell. This was accomplished by appending a specialized boronic acid directly to

Summary, Etc.  

요약Another challenge with biologic therapeutics is overcoming the potential pleiotropic nature of the particular protein or enzyme. This challenge is explicit in the use of angiogenin (ANG) as a potential treatment of amyotrophic lateral sclerosis

Summary, Etc.  

요약In chapter 3, I highlight a specific masking strategy that silences the catalytic activity of ANG under normal physiological conditions. When exposed to reactive oxygen species (ROS) leading to oxidative stress, this mask is removed, and catalyt

Summary, Etc.  

요약In ALS, the up-regulation of ROS in the central nervous system (CNS) is primarily responsible for the motor neuron degeneration characteristic of the disease. The presence of a boronic acid-masking agent engenders ANG with pro-drug characteristi

Summary, Etc.  

요약Boronic acids have also been utilized as important functional groups in medicinal chemistry. For example, VelcadeRTM (bortezomib), is a first-in-class boronic acid-containing protease inhibitor and the first boronic acid drug to be approved by t

Summary, Etc.  

요약In chapter 4, I discuss the development and characterization of a targeted library of small-molecule boronic acids that bind to the thyroxin (T 4) binding pockets and strongly inhibit fibril formation in both wild-type and a common disease varia

Subject Added Entry-Topical Term  

Biochemistry

Subject Added Entry-Topical Term  

Chemistry

Added Entry-Corporate Name  

The University of Wisconsin - Madison Chemistry

Host Item Entry  

Dissertation Abstracts International. 79-11B(E).

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:557752