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Development of Biocatalytic Strategies for the Directed Oxidation of Small Molecule and Macrocyclic Substrates
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Development of Biocatalytic Strategies for the Directed Oxidation of Small Molecule and Macrocyclic Substrates
자료유형  
 학위논문
Control Number  
0015000575
International Standard Book Number  
9780438126855
Dewey Decimal Classification Number  
547
Main Entry-Personal Name  
Gilbert, Michael M.
Publication, Distribution, etc. (Imprint  
[Sl] : University of Michigan, 2018
Publication, Distribution, etc. (Imprint  
Ann Arbor : ProQuest Dissertations & Theses, 2018
Physical Description  
233 p
General Note  
Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
General Note  
Adviser: John Montgomery.
Dissertation Note  
Thesis (Ph.D.)--University of Michigan, 2018.
Summary, Etc.  
요약The cytochrome P450 enzyme PikC has been explored as a robust biocatalyst for late-stage directed C-H hydroxylation reactions in organic synthesis. A collaborative effort between the Sherman, Houk, Podust, and Montgomery labs has resulted in the
Summary, Etc.  
요약Previous studies had illustrated that unnatural substrates can be designed to enable the oxidation of inert C-H bonds. However, the ability to tune and reverse the regioselectivity of oxidations was not possible in prior efforts. This dissertati
Subject Added Entry-Topical Term  
Organic chemistry
Subject Added Entry-Topical Term  
Molecular chemistry
Added Entry-Corporate Name  
University of Michigan Chemistry
Host Item Entry  
Dissertation Abstracts International. 79-12B(E).
Host Item Entry  
Dissertation Abstract International
Electronic Location and Access  
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Control Number  
joongbu:557005
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