자료유형  

 학위논문

Control Number  

0014997609

International Standard Book Number  

9780438206908

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

Mubyana, Kuwabo.

Publication, Distribution, etc. (Imprint  

[Sl] : Rensselaer Polytechnic Institute, 2018

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2018

Physical Description  

127 p

General Note  

Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.

General Note  

Adviser: David T. Corr.

Dissertation Note  

Thesis (Ph.D.)--Rensselaer Polytechnic Institute, 2018.

Summary, Etc.  

요약The current standard for treatment of high grade tendon tears is surgical replacement grafts, however they present the challenge of limited tissue availability (allografts and autografts), donor site morbidity (autografts), and immune rejection

Summary, Etc.  

요약Primed with this knowledge, our laboratory has taken a more biomimetic approach to tendon tissue engineering---a scaffold-free approach that is inspired by key aspects of embryonic tendon development. By seeding a high density of cells into a gr

Summary, Etc.  

요약In the first aim of my doctoral thesis, I developed a method to engineer individual scaffold-free tendon fibers using a micro-molded growth channel, which yielded higher throughput, greater consistency, and higher repeatability in the design of

Summary, Etc.  

요약The second aim examined the response of engineered, scaffold-free, dermal fibroblast-derived fibers to mechanical stimulation, namely cyclic uniaxial strain (designed to mimic motion-induced loading in the embryo), and quasi-static strain (to mi

Summary, Etc.  

요약The final aim of this dissertation investigated the influence of macromolecular crowders on the mechanical properties of engineered scaffold-free tendon fibers. Two crowders, dextran sulfate (DsX) and Ficoll-cocktail, were tested. Fiber formatio

Summary, Etc.  

요약This thesis has provided unique insight on the roles of distinct mechanical stimuli and macromolecular crowding on tendon fiber development and maturation. The knowledge gained on cyclic uniaxial strain, quasi-static loading, and Ficoll-conditio

Subject Added Entry-Topical Term  

Biomedical engineering

Added Entry-Corporate Name  

Rensselaer Polytechnic Institute Biomedical Engineering

Host Item Entry  

Dissertation Abstracts International. 79-12B(E).

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

Control Number  

joongbu:556307