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Structural Characterization of Ribonucleic Acids and Their Complexes by Negative-ion Mode Mass Spectrometry
Structural Characterization of Ribonucleic Acids and Their Complexes by Negative-ion Mode Mass Spectrometry
상세정보
- 자료유형
- 학위논문
- Control Number
- 0015000549
- International Standard Book Number
- 9780438126572
- Dewey Decimal Classification Number
- 540
- Main Entry-Personal Name
- Ileka, Kevin M.
- Publication, Distribution, etc. (Imprint
- [Sl] : University of Michigan, 2018
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2018
- Physical Description
- 146 p
- General Note
- Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
- General Note
- Adviser: Kristina I. Hakansson.
- Dissertation Note
- Thesis (Ph.D.)--University of Michigan, 2018.
- Summary, Etc.
- 요약Ribonucleic acids (RNAs) form complexes with deoxyribonucleic acids, proteins, other RNAs, and smaller ligands. Detailed knowledge of RNA interaction sites provides a basis for understanding functions. With limited analytical techniques availabl
- Summary, Etc.
- 요약Negative-ion electron capture dissociation (niECD) involves &sim
- Summary, Etc.
- 요약Electrospray ionization (ESI) of a model RNA hairpin from native-like (10 mM ammonium acetate) and methanol-containing (up to 50%) solvents resulted in identical charge state distributions, suggesting a minor methanol effect on overall conformat
- Summary, Etc.
- 요약Crosslinking techniques coupled with MS provide an alternative tool for identifying RNA interaction sites. We show that collisional activation can provide full sequence coverage of the RNA moiety within non-covalent RNA-peptide complexes
- Summary, Etc.
- 요약Microfluidics is a highly efficient technology for biological analysis. Microfluidic-type approaches, including nano-ESI and nano-LC, coupled with MS provide several advantages, e.g., limited sample consumption and enhanced sensitivity. In order
- Summary, Etc.
- 요약Overall, this dissertation describes the utility of MS (and its associated tools) for the study of RNA, RNA-small molecule, and RNA-protein complexes.
- Subject Added Entry-Topical Term
- Molecular chemistry
- Added Entry-Corporate Name
- University of Michigan Chemistry
- Host Item Entry
- Dissertation Abstracts International. 79-12B(E).
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:554045
MARC
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■00520190102172830
■020 ▼a9780438126572
■035 ▼a(MiAaPQ)AAI10903051
■035 ▼a(MiAaPQ)umichrackham:001182
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a540
■1001 ▼aIleka, Kevin M.
■24510▼aStructural Characterization of Ribonucleic Acids and Their Complexes by Negative-ion Mode Mass Spectrometry
■260 ▼a[Sl]▼bUniversity of Michigan▼c2018
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2018
■300 ▼a146 p
■500 ▼aSource: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
■500 ▼aAdviser: Kristina I. Hakansson.
■5021 ▼aThesis (Ph.D.)--University of Michigan, 2018.
■520 ▼aRibonucleic acids (RNAs) form complexes with deoxyribonucleic acids, proteins, other RNAs, and smaller ligands. Detailed knowledge of RNA interaction sites provides a basis for understanding functions. With limited analytical techniques availabl
■520 ▼aNegative-ion electron capture dissociation (niECD) involves &sim
■520 ▼aElectrospray ionization (ESI) of a model RNA hairpin from native-like (10 mM ammonium acetate) and methanol-containing (up to 50%) solvents resulted in identical charge state distributions, suggesting a minor methanol effect on overall conformat
■520 ▼aCrosslinking techniques coupled with MS provide an alternative tool for identifying RNA interaction sites. We show that collisional activation can provide full sequence coverage of the RNA moiety within non-covalent RNA-peptide complexes
■520 ▼aMicrofluidics is a highly efficient technology for biological analysis. Microfluidic-type approaches, including nano-ESI and nano-LC, coupled with MS provide several advantages, e.g., limited sample consumption and enhanced sensitivity. In order
■520 ▼aOverall, this dissertation describes the utility of MS (and its associated tools) for the study of RNA, RNA-small molecule, and RNA-protein complexes.
■590 ▼aSchool code: 0127.
■650 4▼aMolecular chemistry
■690 ▼a0431
■71020▼aUniversity of Michigan▼bChemistry.
■7730 ▼tDissertation Abstracts International▼g79-12B(E).
■773 ▼tDissertation Abstract International
■790 ▼a0127
■791 ▼aPh.D.
■792 ▼a2018
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T15000549▼nKERIS
■980 ▼a201812▼f2019
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