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Model Based Visualization of Structure in Biological Data
Model Based Visualization of Structure in Biological Data

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자료유형  
 학위논문
Control Number  
0014999898
International Standard Book Number  
9780438371170
Dewey Decimal Classification Number  
574
Main Entry-Personal Name  
Dey, Kushal K.
Publication, Distribution, etc. (Imprint  
[Sl] : The University of Chicago, 2018
Publication, Distribution, etc. (Imprint  
Ann Arbor : ProQuest Dissertations & Theses, 2018
Physical Description  
130 p
General Note  
Source: Dissertation Abstracts International, Volume: 80-01(E), Section: B.
General Note  
Adviser: Matthew Stephens.
Dissertation Note  
Thesis (Ph.D.)--The University of Chicago, 2018.
Summary, Etc.  
요약Biological Data comes in varied forms and the scale of the data is typically large, which often necessitates distinct modeling frameworks and tools to process, analyze and visually summarize the data. An overarching theme of this doctoral thesis
Summary, Etc.  
요약The second chapter of this thesis extends the concept of a mixed membership model, popularly known as ADMIXTURE model in population genetics and topic model in Natural Language Processing (NLP), to the context of RNA-sequencing read expression
Summary, Etc.  
요약The third chapter extends similar mixed membership models to analyzing DNA damage patterns in ancient DNA (aDNA) samples, and explore and jointly summarize multiple aDNA samples together with modern samples. Applied to a combined data of modern
Summary, Etc.  
요약The visual summary of DNA damage patterns, depicted above, includes a version of logo plot that highlights enrichment and depletion of damage features with respect to a background level of mismatch features computed from modern individuals. We c
Summary, Etc.  
요약In the fifth chapter, we propose an adaptive method for shrinking correlation matrices that leads to a parsimonious representation of the underlying association structure between variables. This method is flexible in handling data matrices with
Subject Added Entry-Topical Term  
Biostatistics
Subject Added Entry-Topical Term  
Bioinformatics
Subject Added Entry-Topical Term  
Genetics
Added Entry-Corporate Name  
The University of Chicago Statistics
Host Item Entry  
Dissertation Abstracts International. 80-01B(E).
Host Item Entry  
Dissertation Abstract International
Electronic Location and Access  
로그인을 한후 보실 수 있는 자료입니다.
Control Number  
joongbu:553488

MARC

 008190618s2018                                          c    eng  d
■001000014999898
■00520190102172548
■020    ▼a9780438371170
■035    ▼a(MiAaPQ)AAI10843117
■035    ▼a(MiAaPQ)uchicago:14510
■040    ▼aMiAaPQ▼cMiAaPQ
■0820  ▼a574
■1001  ▼aDey,  Kushal  K.
■24510▼aModel  Based  Visualization  of  Structure  in  Biological  Data
■260    ▼a[Sl]▼bThe  University  of  Chicago▼c2018
■260  1▼aAnn  Arbor▼bProQuest  Dissertations  &  Theses▼c2018
■300    ▼a130  p
■500    ▼aSource:  Dissertation  Abstracts  International,  Volume:  80-01(E),  Section:  B.
■500    ▼aAdviser:  Matthew  Stephens.
■5021  ▼aThesis  (Ph.D.)--The  University  of  Chicago,  2018.
■520    ▼aBiological  Data  comes  in  varied  forms  and  the  scale  of  the  data  is  typically  large,  which  often  necessitates  distinct  modeling  frameworks  and  tools  to  process,  analyze  and  visually  summarize  the  data.  An  overarching  theme  of  this  doctoral  thesis
■520    ▼aThe  second  chapter  of  this  thesis  extends  the  concept  of  a  mixed  membership  model,  popularly  known  as  ADMIXTURE  model  in  population  genetics  and    topic  model  in  Natural  Language  Processing  (NLP),  to  the  context  of  RNA-sequencing  read  expression  
■520    ▼aThe  third  chapter  extends  similar  mixed  membership  models  to  analyzing  DNA  damage  patterns  in  ancient  DNA  (aDNA)  samples,  and  explore  and  jointly  summarize  multiple  aDNA  samples  together  with  modern  samples.  Applied  to  a  combined  data  of  modern  
■520    ▼aThe  visual  summary  of  DNA  damage  patterns,  depicted  above,  includes  a  version  of  logo  plot  that  highlights  enrichment  and  depletion  of  damage  features  with  respect  to  a  background  level  of  mismatch  features  computed  from  modern  individuals.  We  c
■520    ▼aIn  the  fifth  chapter,  we  propose  an  adaptive  method  for  shrinking  correlation  matrices  that  leads  to  a  parsimonious  representation  of  the  underlying  association  structure  between  variables.  This  method  is  flexible  in  handling  data  matrices  with  
■590    ▼aSchool  code:  0330.
■650  4▼aBiostatistics
■650  4▼aBioinformatics
■650  4▼aGenetics
■690    ▼a0308
■690    ▼a0715
■690    ▼a0369
■71020▼aThe  University  of  Chicago▼bStatistics.
■7730  ▼tDissertation  Abstracts  International▼g80-01B(E).
■773    ▼tDissertation  Abstract  International
■790    ▼a0330
■791    ▼aPh.D.
■792    ▼a2018
■793    ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T14999898▼nKERIS
■980    ▼a201812▼f2019

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