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Survival Motor Neuron Protein Interaction Partners in Drosophila melanogaster
Survival Motor Neuron Protein Interaction Partners in Drosophila melanogaster
상세정보
- 자료유형
- 학위논문
- Control Number
- 0014996834
- International Standard Book Number
- 9780438033368
- Dewey Decimal Classification Number
- 574
- Main Entry-Personal Name
- Gray, Kelsey Marie.
- Publication, Distribution, etc. (Imprint
- [Sl] : The University of North Carolina at Chapel Hill, 2018
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2018
- Physical Description
- 139 p
- General Note
- Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
- General Note
- Advisers: Arnold G. Matera
- Dissertation Note
- Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
- Summary, Etc.
- 요약Spinal Muscular Atrophy (SMA) is a neuromuscular disorder that results from biallelic loss-of-function mutations in the human survival motor neuron 1 (SMN1) gene. Tissue-specific and housekeeping functions have been ascribed to SMN
- Summary, Etc.
- 요약We also identified Slmb, SkpA, and Cullin 1 as being highly enriched in Flag-SMN samples as compared to the control sample. Together, these proteins comprise the SCFSlmb E3 ubiquitin ligase. These interactions were verified in Drosophila S2 cell
- Summary, Etc.
- 요약We identified additional protein interactions of SMN with CG2941, nucleosome assembly protein 1 (Nap1), and Bendless (Ben). Each of these interactions was verified in cell culture or using antibodies generated specifically for the protein of int
- Summary, Etc.
- 요약We have examined SMN protein interactions in the context of developing Drosophila melanogaster embryos, with follow-up studies in mouse, and human systems. When SMN is unable to self-oligomerize, the Slmb degron is highly accessible, and thus S
- Subject Added Entry-Topical Term
- Molecular biology
- Subject Added Entry-Topical Term
- Genetics
- Added Entry-Corporate Name
- The University of North Carolina at Chapel Hill Genetics and Molecular Biology
- Host Item Entry
- Dissertation Abstracts International. 79-10B(E).
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:553265
MARC
008190618s2018 c eng d■001000014996834
■00520190102171315
■020 ▼a9780438033368
■035 ▼a(MiAaPQ)AAI10744561
■035 ▼a(MiAaPQ)unc:17501
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aGray, Kelsey Marie.
■24510▼aSurvival Motor Neuron Protein Interaction Partners in Drosophila melanogaster
■260 ▼a[Sl]▼bThe University of North Carolina at Chapel Hill▼c2018
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2018
■300 ▼a139 p
■500 ▼aSource: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
■500 ▼aAdvisers: Arnold G. Matera
■5021 ▼aThesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
■520 ▼aSpinal Muscular Atrophy (SMA) is a neuromuscular disorder that results from biallelic loss-of-function mutations in the human survival motor neuron 1 (SMN1) gene. Tissue-specific and housekeeping functions have been ascribed to SMN
■520 ▼aWe also identified Slmb, SkpA, and Cullin 1 as being highly enriched in Flag-SMN samples as compared to the control sample. Together, these proteins comprise the SCFSlmb E3 ubiquitin ligase. These interactions were verified in Drosophila S2 cell
■520 ▼aWe identified additional protein interactions of SMN with CG2941, nucleosome assembly protein 1 (Nap1), and Bendless (Ben). Each of these interactions was verified in cell culture or using antibodies generated specifically for the protein of int
■520 ▼aWe have examined SMN protein interactions in the context of developing Drosophila melanogaster embryos, with follow-up studies in mouse, and human systems. When SMN is unable to self-oligomerize, the Slmb degron is highly accessible, and thus S
■590 ▼aSchool code: 0153.
■650 4▼aMolecular biology
■650 4▼aGenetics
■690 ▼a0307
■690 ▼a0369
■71020▼aThe University of North Carolina at Chapel Hill▼bGenetics and Molecular Biology.
■7730 ▼tDissertation Abstracts International▼g79-10B(E).
■773 ▼tDissertation Abstract International
■790 ▼a0153
■791 ▼aPh.D.
■792 ▼a2018
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T14996834▼nKERIS
■980 ▼a201812▼f2019
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